Elucidation ofPax and Wnt gene functions during - ETH E


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PDF Elucidation ofPax and Wnt gene functions during pronephric kidney

The amphibian pronephric kidney is a convenient model system for studies on renal development It constitutes a simple and functional embryonie excretory 

  • Paired-box (PAX) genes encode a family of highly conserved transcription factors found in vertebrates and invertebrates.

  • What is the function of PAX1 in humans?

    PAX1 is essential for development and function of the human thymus.
    Temporal and spatial expression of Sox9, Pax1, TGF-beta1 and type I and II collagen in human intervertebral disc development.
    Paired Box-1 (PAX.
    1) Activates Multiple Phosphatases and Inhibits Kinase Cascades in Cervical Cancer.

  • What is the function of the PAX gene?

    Pax genes are a family of developmental control genes that encode nuclear transcription factors.
    They are characterized by the presence of the paired domain, a conserved amino acid motif with DNA-binding activity.

  • PAX proteins have been implicated as regulators of embryogenesis and as crucial factors in maintaining the pluripotency of stem cell populations and cell-lineage specification during development [6, 10, 11]. Mutations of PAX are associated with major developmental defects.
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