What is the function of androgen binding protein?
Androgen binding protein, ABP, was initially characterized as a Sertoli cell product in rodents and other small mammals. In these species it is thought to function to concentrate androgens in the seminiferous tubules and deliver the steroid hormone to developing spermatocytes and spermatids.
Where is androgen-binding protein synthesized?
Androgen-binding protein (ABP) is synthesized by the Sertoli cell in the testis, where ~80% is secreted into the luminal fluid and the other ~20% is secreted into the interstitial compartment and taken up into the systemic circulation.
What is the relationship between serum FSH and androgen-binding protein?
Rich and de Kretser (1977) damaged rat seminiferous epithelium by several methods and found a relationship between elevated serum FSH and a reduced ability of the Sertoli cells to secrete androgen-binding protein.
What is androgen action?
Action Androgen action involves pre-receptor, receptor and post-receptor mechanisms that are centered on the binding of testosterone (or an analog) to the androgen receptor. Testosterone undergoes pre-receptor activation by conversion to potent bioactive metabolites, DHT and estradiol.
ABP: la protéine testiculaire de liaison des androgènes