Wobble hypothesis


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According to wobble hypothesis the first two bases of a codon pair In 1966 Crick postulated the 'wobble hypothesis' to account for the degeneracy

PDF Wobble Hypothesis

Proposed by Crick in 1966 According to this hypothesis the base in the first position of anti-codon on tRNA is usually an abnormal base like inosine 

PDF mechanism of wobbling phenomenon :

wobble hypothesis: Mechanism by which • tRNA can recognize more than one codon for u Specific amino acid Codon - cinticodon pairing follows traditioncu

PDF FACULTY OF ENGINEERING &TECHNOLOGY DEPARTMENT OF

Crick (1996) proposed the 'wobble hypothesis' to explain the degeneracy of the genetic code • Except for tryptophan and methionine more than one codons 

PDF THE GENETIC CODE

According to the Wobble hypothesis the base position at the 5′- end of anticodon is the “wobble position” Two bases of anticodon from 3′-end are 

  • What is an example of a wobble theory?

    A wobble base pair is a pairing between two nucleotides in RNA molecules that does not follow Watson-Crick base pair rules.
    The four main wobble base pairs are guanine-uracil (G-U), hypoxanthine-uracil (I-U), hypoxanthine-adenine (I-A), and hypoxanthine-cytosine (I-C).

  • What is the super Wobble Hypothesis?

    'Superwobble', in which a tRNA species with an unmodified U in the wobble position reads all four nucleotides in the third codon position, represents one possible mechanism for how a reduced tRNA set could still suffice.

  • What is the Wobble Hypothesis?

    A theory to explain the partial degeneracy of the genetic code due to the fact that some t-RNA molecules can recognize more than one codon.
    The theory proposes that the first two bases in the codon and anticodon will form complementary pairs in the normal antiparallel fashion.

  • The Wobble Hypothesis describes how one amino acid can be coded for by several codons.
    The third nucleotide in a codon is referred to as the wobble position.
    There are two main properties of this nucleotide.
    The cognate tRNA's binding to a codon in an mRNA is substantially more "loose" in the codon's third position.

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